GAMMA TROPOCOLLAGEN: A REVERSIBLY DENATURABLE COLLAGEN MACROMOLECULE
نویسندگان
چکیده
منابع مشابه
A Subunit Model for the Tropocollagen Macromolecule.
In this article is presented a novel subunit model for the tropocollagen (TC) macromolecule, the monomeric unit of soluble collagen.1 The TC macromolecule is a rigid rod of definite length composed of three helical polypeptide strands that are equal (or very nearly equal) in length.2 4 The strands are of two types chemically, designated a1 and a2.4 Each macromolecule contains two al strands and...
متن کاملThe Charge Profile of the Tropocollagen Macromolecule and the Packing Arrangement in Native-type Collagen Fibrils.
* Supported in part by a grant from the American Cancer Society. t Scholar in Cancer Research of the American Cancer Society. t Post-doctoral fellowship support was derived from a research training grant of the U.S. Public Health Service. Present address: Department of Biochemistry, University of Oxford, Oxford, England. 1 Standerfer, S. B., and P. Handler, Proc. Soc. Exper. Biol. Med., 90, 270...
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When soluble earthworm cuticle collagen molecules are subjected to the shearing forces of a flow birefringence instrument, they are broken into particles approximately half the original size. The broken particles resemble vertebrate tropocollagen molecules in their hydrodynamic properties, in levorotatory powers, and in their appearance in the electron microscope. Most significantly, the broken...
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density distribution has recently been directly demonstrated in electron micrographs of formaldehyde-fixed SIS-type aggregates by Kuhn, K., U. Hofmann, and W. Grassmann (Naturwiss., 46, 512 1959). I For this purpose the segments were stained by exposure to 0.002 M uranyl nitrate for 1 minute and washed with distilled water before drying on the grid. Under these conditions the uranium in solutio...
متن کاملTheory of Zone Electrophoresis of Reversibly Interacting Systems. Two Zones from a Single Macromolecule.
where P represents a macromolecular ion in solution and P(HA), its complex with n moles of a small uncharged constituent, HA, of the solvent medium. It was assumed that the complex migrates with a greater electrophoretic mobility than the uncomplexed macromolecule and that equilibrium is established instantaneously. Computer solution of the conservation equations showed that under appropriate c...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1961
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.47.12.1914